In Alzheimer's, excess tau protein damages brain's GPS
It is a grid cell from the entorhinal cortex (EC) of the mouse mind, firing repeatedly and uniformly in a grid-like sample. When a mouse strikes by way of its surroundings, grid cells are activated, with every cell representing a particular location. This creates a triangular coordinate system that permits for spatial navigation. A number of grid cells create a triangular coordinate system that permits for spatial navigation. The buildup of tau protein within the mind of a mouse mannequin of Alzheimer's illness was proven to disrupt the operate of grid cells, inflicting issues with navigation. The findings explains why Alzheimer's sufferers are inclined to wander and get misplaced. Credit score: Lab of Karen Duff, PhD, Columbia College Medical Heart Columbia College Medical Heart (CUMC) researchers have found that the spatial disorientation that res...